Recombinant Human Stromal cell-derived factor 1 protein(CXCL12) (Active)
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產(chǎn)品名稱(chēng): Recombinant Human Stromal cell-derived factor 1 protein(CXCL12) (Active)
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Recombinant Human Stromal cell-derived factor 1 protein(CXCL12) (Active)
Recombinant Human Stromal cell-derived factor 1 protein(CXCL12) (Active)
的詳細(xì)介紹
產(chǎn)品類(lèi)型:Chemokine
產(chǎn)品名稱(chēng):Recombinant Human Stromal cell-derived factor 1 protein(CXCL12) (Active)
uniprot號(hào):
規(guī)格:
圖像:
基因名稱(chēng):
CXCL12
別名:
SDF-1, C-X-C motif chemokine 12, Intercrine reduced in hepatomas, IRH, hIRH
種屬:
Homo sapiens (Human)
蛋白描述:
Partial of Isoform Gamma
PubMed ID:
7490086; 16626895; 14702039; 16344560; 15164054; 15489334; 8752281; 9427609; 10446158; 11069075; 11859124; 14525775; 16107333; 15741341; 16725153; 18802065; 19255243; 22457824; 9384579; 9618518; 10954912; 15588815; 17264079; 17357154; 18799424; 19551879; 20077567
分子量:
11.6 kDa
標(biāo)簽信息:
Tag-Free
來(lái)源:
E.Coli
純度:
>96% as determined by SDS?PAGE and HPLC.
緩沖液:
0.2 μm filtered PBS, pH 7.4 ,lyophilized
內(nèi)毒素:
Less than 1.0 EU/μg as determined by LAL method.
生物活性:
Fully
biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using PHA and rHuIL?2 activated human peripheral blood T?lymphocytes is in a concentration range of 30?100 ng/ml.
SDF1_HUMAN
參考文獻(xiàn):
Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. {ECO:0000269|PubMed:11069075, ECO:0000269|PubMed:11859124, ECO:0000269|PubMed:16107333, ECO:0000269|PubMed:18802065, ECO:0000269|PubMed:19255243, ECO:0000269|PubMed:8752281}.
氨基酸序列:
GKPVSLSYRC PCRFFESHVA RANVKHLKIL NTPNCALQIV ARLKNNNRQV CIDPKLKWIQ EYLEKALNKG RREEKVGKKE KIGKKKRQKK RKAAQKRKN
表達(dá)區(qū)域:
21-119aa
研究領(lǐng)域:
Immunology
