Recombinant Human Interleukin-11 protein(IL11) (Active)
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產(chǎn)品名稱: Recombinant Human Interleukin-11 protein(IL11) (Active)
產(chǎn)品型號:
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簡單介紹
Recombinant Human Interleukin-11 protein(IL11) (Active)
Recombinant Human Interleukin-11 protein(IL11) (Active)
的詳細(xì)介紹
產(chǎn)品類型:Interleukin
產(chǎn)品名稱:Recombinant Human Interleukin-11 protein(IL11) (Active)
uniprot號:
規(guī)格:
￥620
圖像:
基因名稱:
IL11
別名:
IL-11, AGIF, Oprelvekin
種屬:
Homo sapiens (Human)
蛋白描述:
Full Length of Mature Protein
PubMed ID:
2145578; 1828438; 1386338; 14702039; 15057824; 15489334; 12919066; 25195742
分子量:
19.1 kDa
標(biāo)簽信息:
Tag-Free
來源:
E.Coli
純度:
>95% as determined by SDS-PAGE and HPLC.
緩沖液:
0.2 μm filtered PBS, pH 7.4 ,lyophilized
內(nèi)毒素:
Less than 1.0 EU/μg as determined by LAL method.
生物活性:
Fully
biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine B9-11 cells is less than 1 ng/ml, corresponding to a specific activity of >1.0x10
6 IU/mg.
IL11_HUMAN
參考文獻(xiàn):
Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:2145578). Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation (PubMed:12919066). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. {ECO:0000250|UniProtKB:P47873, ECO:0000269|PubMed:12919066, ECO:0000269|PubMed:2145578}.
氨基酸序列:
M+PGPPPGPPR VSPDPRAELD STVLLTRSLL ADTRQLAAQL RDKFPADGDH NLDSLPTLAM SAGALGALQL PGVLTRLRAD LLSYLRHVQW LRRAGGSSLK TLEPELGTLQ ARLDRLLRRL QLLMSRLALP QPPPDPPAPP LAPPSSAWGG IRAAHAILGG LHLTLDWAVR GLLLLKTRL
表達(dá)區(qū)域:
22-199aa
研究領(lǐng)域:
Immunology
