Recombinant Mouse Interleukin-33 protein(Il33) (Active)
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產(chǎn)品名稱: Recombinant Mouse Interleukin-33 protein(Il33) (Active)
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Recombinant Mouse Interleukin-33 protein(Il33) (Active)
Recombinant Mouse Interleukin-33 protein(Il33) (Active)
的詳細(xì)介紹
產(chǎn)品類型:Interleukin
產(chǎn)品名稱:Recombinant Mouse Interleukin-33 protein(Il33) (Active)
uniprot號(hào):
規(guī)格:
￥620
圖像:
基因名稱:
Il33
別名:
IL-33,; Interleukin-33109-266,]
種屬:
Mus musculus (Mouse)
蛋白描述:
Full Length of Mature Protein
PubMed ID:
16286016; 16141072; 15489334; 19465481; 21734074; 22307629
分子量:
17.5 kDa
標(biāo)簽信息:
Tag-Free
來(lái)源:
E.Coli
純度:
>98% as determined by SDS-PAGE and HPLC.
緩沖液:
0.2 μm filtered PBS, and 1 mM EDTA ,lyophilized
內(nèi)毒素:
Less than 1.0 EU/μg as determined by LAL method.
生物活性:
Fully
biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine D10S cells is less than 0.5 ng/ml, corresponding to a specific activity of >2.0x10
6 IU/mg.
IL33_MOUSE
參考文獻(xiàn):
Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury.; In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets. This form is rapidely lost upon angiogenic or proinflammatory activation.
氨基酸序列:
SIQGTSLLTQ SPASLSTYND QSVSFVLENG CYVINVDDSG KDQEQDQVLL RYYESPCPAS QSGDGVDGKK LMVNMSPIKD TDIWLHANDK DYSVELQRGD VSPPEQAFFV LHKKSSDFVS FECKNLPGTY IGVKDNQLAL VEEKDESCNN IMFKLSKI
表達(dá)區(qū)域:
109-266aa
研究領(lǐng)域:
Immunology
