Recombinant Mouse Interleukin-11 protein(Il11) (Active)
如果您對該產(chǎn)品感興趣的話,可以
產(chǎn)品名稱: Recombinant Mouse Interleukin-11 protein(Il11) (Active)
產(chǎn)品型號:
產(chǎn)品展商: 其它品牌
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
Recombinant Mouse Interleukin-11 protein(Il11) (Active)
Recombinant Mouse Interleukin-11 protein(Il11) (Active)
的詳細(xì)介紹
產(chǎn)品類型:Interleukin
產(chǎn)品名稱:Recombinant Mouse Interleukin-11 protein(Il11) (Active)
uniprot號:
規(guī)格:
￥620
圖像:
基因名稱:
Il11
別名:
IL-11
種屬:
Mus musculus (Mouse)
蛋白描述:
Full Length of Mature Protein
PubMed ID:
8913282; 10026196; 22253262; 23948300
分子量:
19.1 kDa
標(biāo)簽信息:
Tag-Free
來源:
E.Coli
純度:
>97% as determined by SDS-PAGE and HPLC.
緩沖液:
0.2 μm filtered PBS, pH 7.4 ,lyophilized
內(nèi)毒素:
Less than 1.0 EU/μg as determined by LAL method.
生物活性:
Fully
biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine T11 cells is less than 2 ng/ml, corresponding to a specific activity of >5.0x10
5 IU/mg.
IL11_MOUSE
參考文獻(xiàn):
Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:8913282). Also promotes the proliferation of hepatocytes in response to liver damage (PubMed:22253262). Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation, also in the context of various cancers (PubMed:10026196, PubMed:23948300). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3 (PubMed:23948300, PubMed:22253262). {ECO:0000269|PubMed:10026196, ECO:0000269|PubMed:22253262, ECO:0000269|PubMed:23948300, ECO:0000269|PubMed:8913282}.
氨基酸序列:
M+PGPPAGSPR VSSDPRADLD SAVLLTRSLL ADTRQLAAQM RDKFPADGDHSLDSLPTLAM SAGTLGSLQL PGVLTRLRVD LMSYLRHVQW LRRAGGPSLKTLEPELGALQ ARLERLLRRL QLLMSRLALP QAAPDQPVIP LGPPASAWGSIRAAHAILGG LHLTLDWAVR GLLLLKTRL
表達(dá)區(qū)域:
22-199aa
研究領(lǐng)域:
Immunology
